|
KMID : 0361020220650080437
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2022 Volume.65 No. 8 p.437 ~ p.443
|
|
|
Expression of Toll-Like Receptor Messenger Ribonucleic Acid in the Distal Facial Nerve After Facial Nerve Injury
|
|
Min Hye-Kyu
Lee Jae-Min
Jung Jun-Yang
Kim Young-Il
Kim Sang-Hoon
Yeo Seung-Geun
|
|
|
Abstract
|
|
|
Background and Objectives This study aimed to evaluate whether Toll-like receptors(TLRs) messenger ribonucleic acid (mRNA) were expressed in the facial nerve after incurringa crush or an injury of the facial nerve.
Materials and Method An adult Sprague-Dawley underwent a crush or injury of the unilateralfacial nerve. The crush or injury was incurred by a cutting at the midpoint between thefacial nerve trunk and its branch. The whisker movement of vibrissae muscle was examined 4and 14 days after injury. Real-time polymerase chain reaction was performed for the normalfacial nerve taken from the left side and the damaged nerve taken from the right side.
Results On the 4th day of injury, the expression of TLR 9, 13 mRNA was significantly lowerin the crush and injured groups than in the control group (p<0.05). On the 14th day of injury,the expression of TLR 2 mRNA was significantly higher in the injured group than in thecontrol group (p<0.05).
Conclusion The expressions of TLR 9, 13 mRNA in the distal facial nerve after injury inthe crush and injured groups were significantly lower than that in the control group, but theexpression of TLR 2 mRNA in the injured group was significantly higher. Therefore, TLRsmay be involved in facial nerve damage and regeneration.
|
|
|
KEYWORD
|
|
|
Facial nerve injury, Facial palsy, Nerve regeneration, Toll like receptor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|